Comparison:Article Title: Bismuth-thiol compositions and methods of use
Article Snippet: As can be seen from this data below in Table 4, the bismuth-thiols are notably and consistently more potent than both amikacin and clarithromycin (most dramatically when considering the MABSC strain ATCC 19977, which was induced to be macrolide-resistant). .. TABLE 4A Comparison of conventional antibiotics vs BisEDT and BisBDT activity against bacterial strains SUMMARY OF MIC RESULTS Special Strain MIC MIC MIC MIC Strain characteristics (mcg/mL) (mcg/mL) (mcg/mL) (mcg/mL) Designation Species (if any) Amikacin Clarithromycin Bis-EDT Bis-BDT ATCC 19977 M abscessus/massiliense Macrolide resistant 8 2 >32 2 0.06 2 <0.03 2 complex (inducible) AMT0130-8 M abscessus/massiliense 16 2 1 0.06 2 <0.03 2 complex AMT153-9 M abscessus/massiliense 32 2 2 0.13 2 <0.03 2 complex AMT0068-40 M abscessus/massiliense 32 2 1 0.25 2 0.06 2 complex AMT0119-7 M abscessus/massiliense 32 2 1 0.06 2 <0.03 2 complex AMT0493-2 M abscessus/massiliense Amikacin resistant >64 2 2 0.5 2 0.125 2 complex AGR1 P. aeruginosa 16 na 1 1 AGR14 P. aeruginosa Multi-drug resistant >64 na 0.5 1 MR14 P. aeruginosa Multi-drug resistant >64 na 1 1 SM21 S. maltophilia 64 na 0.25 0.13 AX1 Achromobacter spp. .. 64 na 1 1 AX4 A. xylosoxidans >64 na 0.25 0.5 BC5b B. multivorans (B cepacia complex) >64 na 0.25 1 BC15 B. cenocepacia (B cepacia complex) >64 na 2 4 BC17 B. cepacia (B cepacia complex) >64 na 8 8 AU197 B. cenocepacia (B cepacia complex) >64 na 0.5 4 TABLE 4B BisEDT and BisBDT MIC against control bacterial strains ATCC or other strains used to control for drug activity (see detailed data for measured MICs Expected results (acceptable range) mcg/mL with each assay set-up) (per CLSI M100-S24 or provided by Microbion) Strain Species Amikacin Clarithromycin BisEDT BisBDT ATCC 29213 S. aureus 2 (1-4) 0.25 (0.12-0.5) 0.25-0.5 (0.13-1) 0.25 (0.12-0.5) ATCC 25922 E. coli 1-2 (0.5-4) na 1 (0.5-2) na Evaluation of BT compound effect on cytotoxicity on a fully differentiated human airway epithelium (MUCILAIRTM) The aim of this study is to evaluate the potential local toxic effect of BisEDT on airway epithelium.
Article Title: Bismuth-thiol compositions and methods of use
Article Snippet: As can be seen from this data below in Table 4, the bismuth-thiols are notably and consistently more potent than both amikacin and clarithromycin (most dramatically when considering the MABSC strain ATCC 19977, which was induced to be macrolide-resistant). .. TABLE 4A Comparison of conventional antibiotics vs BisEDT and BisBDT activity against bacterial strains SUMMARY OF MIC RESULTS Special Strain MIC MIC MIC MIC Strain characteristics (mcg/mL) (mcg/mL) (mcg/mL) (mcg/mL) Designation Species (if any) Amikacin Clarithromycin Bis-EDT Bis-BDT ATCC 19977 M abscessus/massiliense Macrolide resistant 8 2 >32 2 0.06 2 <0.03 2 complex (inducible) AMT0130-8 M abscessus/massiliense 16 2 1 0.06 2 <0.03 2 complex AMT153-9 M abscessus/massiliense 32 2 2 0.13 2 <0.03 2 complex AMT0068-40 M abscessus/massiliense 32 2 1 0.25 2 0.06 2 complex AMT0119-7 M abscessus/massiliense 32 2 1 0.06 2 <0.03 2 complex AMT0493-2 M abscessus/massiliense Amikacin resistant >64 2 2 0.5 2 0.125 2 complex AGR1 P. aeruginosa 16 na 1 1 AGR14 P. aeruginosa Multi-drug resistant >64 na 0.5 1 MR14 P. aeruginosa Multi-drug resistant >64 na 1 1 SM21 S. maltophilia 64 na 0.25 0.13 AX1 Achromobacter spp. .. 64 na 1 1 AX4 A. xylosoxidans >64 na 0.25 0.5 BC5b B. multivorans (B cepacia complex) >64 na 0.25 1 BC15 B. cenocepacia (B cepacia complex) >64 na 2 4 BC17 B. cepacia (B cepacia complex) >64 na 8 8 AU197 B. cenocepacia (B cepacia complex) >64 na 0.5 4 TABLE 4B BisEDT and BisBDT MIC against control bacterial strains ATCC or other strains used to control for drug activity Expected results (acceptable range) mcg/mL (see detailed data for measured MICs with each assay set-up) (per CLSI M100-S24 or provided by Microbion) Strain Species Amikacin Clarithromycin BisEDT BisBDT ATCC 29213 S. aureus 2 (1-4) 0.25 (0.12-0.5) 0.25-0.5 (0.13-1) 0.25 (0.12-0.5) ATCC 25922 E. coli 1-2 (0.5-4) na 1 (0.5-2) na Evaluation of BT Compound Effect on Cytotoxicity on a Fully Differentiated Human Airway Epithelium (MUCILAIRTM) The aim of this study is to evaluate the potential local toxic effect of BisEDT on airway epithelium.
Activity Assay:Article Title: Bismuth-thiol compositions and methods of use
Article Snippet: As can be seen from this data below in Table 4, the bismuth-thiols are notably and consistently more potent than both amikacin and clarithromycin (most dramatically when considering the MABSC strain ATCC 19977, which was induced to be macrolide-resistant). .. TABLE 4A Comparison of conventional antibiotics vs BisEDT and BisBDT activity against bacterial strains SUMMARY OF MIC RESULTS Special Strain MIC MIC MIC MIC Strain characteristics (mcg/mL) (mcg/mL) (mcg/mL) (mcg/mL) Designation Species (if any) Amikacin Clarithromycin Bis-EDT Bis-BDT ATCC 19977 M abscessus/massiliense Macrolide resistant 8 2 >32 2 0.06 2 <0.03 2 complex (inducible) AMT0130-8 M abscessus/massiliense 16 2 1 0.06 2 <0.03 2 complex AMT153-9 M abscessus/massiliense 32 2 2 0.13 2 <0.03 2 complex AMT0068-40 M abscessus/massiliense 32 2 1 0.25 2 0.06 2 complex AMT0119-7 M abscessus/massiliense 32 2 1 0.06 2 <0.03 2 complex AMT0493-2 M abscessus/massiliense Amikacin resistant >64 2 2 0.5 2 0.125 2 complex AGR1 P. aeruginosa 16 na 1 1 AGR14 P. aeruginosa Multi-drug resistant >64 na 0.5 1 MR14 P. aeruginosa Multi-drug resistant >64 na 1 1 SM21 S. maltophilia 64 na 0.25 0.13 AX1 Achromobacter spp. .. 64 na 1 1 AX4 A. xylosoxidans >64 na 0.25 0.5 BC5b B. multivorans (B cepacia complex) >64 na 0.25 1 BC15 B. cenocepacia (B cepacia complex) >64 na 2 4 BC17 B. cepacia (B cepacia complex) >64 na 8 8 AU197 B. cenocepacia (B cepacia complex) >64 na 0.5 4 TABLE 4B BisEDT and BisBDT MIC against control bacterial strains ATCC or other strains used to control for drug activity (see detailed data for measured MICs Expected results (acceptable range) mcg/mL with each assay set-up) (per CLSI M100-S24 or provided by Microbion) Strain Species Amikacin Clarithromycin BisEDT BisBDT ATCC 29213 S. aureus 2 (1-4) 0.25 (0.12-0.5) 0.25-0.5 (0.13-1) 0.25 (0.12-0.5) ATCC 25922 E. coli 1-2 (0.5-4) na 1 (0.5-2) na Evaluation of BT compound effect on cytotoxicity on a fully differentiated human airway epithelium (MUCILAIRTM) The aim of this study is to evaluate the potential local toxic effect of BisEDT on airway epithelium.
Article Title: Bismuth-thiol compositions and methods of use
Article Snippet: As can be seen from this data below in Table 4, the bismuth-thiols are notably and consistently more potent than both amikacin and clarithromycin (most dramatically when considering the MABSC strain ATCC 19977, which was induced to be macrolide-resistant). .. TABLE 4A Comparison of conventional antibiotics vs BisEDT and BisBDT activity against bacterial strains SUMMARY OF MIC RESULTS Special Strain MIC MIC MIC MIC Strain characteristics (mcg/mL) (mcg/mL) (mcg/mL) (mcg/mL) Designation Species (if any) Amikacin Clarithromycin Bis-EDT Bis-BDT ATCC 19977 M abscessus/massiliense Macrolide resistant 8 2 >32 2 0.06 2 <0.03 2 complex (inducible) AMT0130-8 M abscessus/massiliense 16 2 1 0.06 2 <0.03 2 complex AMT153-9 M abscessus/massiliense 32 2 2 0.13 2 <0.03 2 complex AMT0068-40 M abscessus/massiliense 32 2 1 0.25 2 0.06 2 complex AMT0119-7 M abscessus/massiliense 32 2 1 0.06 2 <0.03 2 complex AMT0493-2 M abscessus/massiliense Amikacin resistant >64 2 2 0.5 2 0.125 2 complex AGR1 P. aeruginosa 16 na 1 1 AGR14 P. aeruginosa Multi-drug resistant >64 na 0.5 1 MR14 P. aeruginosa Multi-drug resistant >64 na 1 1 SM21 S. maltophilia 64 na 0.25 0.13 AX1 Achromobacter spp. .. 64 na 1 1 AX4 A. xylosoxidans >64 na 0.25 0.5 BC5b B. multivorans (B cepacia complex) >64 na 0.25 1 BC15 B. cenocepacia (B cepacia complex) >64 na 2 4 BC17 B. cepacia (B cepacia complex) >64 na 8 8 AU197 B. cenocepacia (B cepacia complex) >64 na 0.5 4 TABLE 4B BisEDT and BisBDT MIC against control bacterial strains ATCC or other strains used to control for drug activity Expected results (acceptable range) mcg/mL (see detailed data for measured MICs with each assay set-up) (per CLSI M100-S24 or provided by Microbion) Strain Species Amikacin Clarithromycin BisEDT BisBDT ATCC 29213 S. aureus 2 (1-4) 0.25 (0.12-0.5) 0.25-0.5 (0.13-1) 0.25 (0.12-0.5) ATCC 25922 E. coli 1-2 (0.5-4) na 1 (0.5-2) na Evaluation of BT Compound Effect on Cytotoxicity on a Fully Differentiated Human Airway Epithelium (MUCILAIRTM) The aim of this study is to evaluate the potential local toxic effect of BisEDT on airway epithelium.
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